WATERLOO Waterloo can be found in Southern Ontario and is the smallest of three cities in the Regional Municipality of Waterloo.. Kitchener Located in Southern Ontario, some 100 kilometres west of Toronto, Kitchener is a city with a rich and fascinating history.. Cambridge Located in Southern Ontario at the confluence of the Speed and Grand rivers, Cambridge is a wildly interesting city and a must-see for any traveler.. Guelph Nestled in southwestern Ontario, Guelph is roughly 28 kilometres east of Kitchener and 100 kilometres west of Downtown Toronto..